解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent tra...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.97
更新日期:2009-08-01 00:00:00
abstract::Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000-4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. T...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.147
更新日期:2009-07-01 00:00:00
abstract::The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondr...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.86
更新日期:2009-07-01 00:00:00
abstract::The Carma1-Bcl10-Malt1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical IkappaB kinase (IKK)/NF (nuclear factor)-kappaB pathway. Earlier studies have indicated that the COP9 signalosome (CSN), a pleiotropic regulator of the ubiquitin/26S proteasome system, controls antigen responses in T cells....
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.64
更新日期:2009-06-01 00:00:00
abstract::The influence of circadian rhythms on memory has long been studied; however, the molecular prerequisites for their interaction remain elusive. The hippocampus, which is a region of the brain important for long-term memory formation and temporary maintenance, shows circadian rhythmicity in pathways central to the memor...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.123
更新日期:2009-06-01 00:00:00
abstract::ARGONAUTE 1 (AGO1) slices endogenous messenger RNAs (mRNAs) during both microRNA (miRNA)- and short interfering RNA (siRNA)-guided post-transcriptional silencing. We have previously reported that AGO1 homeostasis is maintained through the repressive action of miR168 on AGO1 mRNA and the stabilizing effect of AGO1 prot...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2009.32
更新日期:2009-05-01 00:00:00
abstract::The COP9 signalosome (CSN) is a highly conserved protein complex that was originally described as a repressor of light-dependent growth and transcription in Arabidopsis. The most studied CSN function is the regulation of protein degradation, which occurs primarily through the removal of the ubiquitin-like modifier Ned...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.33
更新日期:2009-04-01 00:00:00
abstract::PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by f...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2009.21
更新日期:2009-03-01 00:00:00
abstract::Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigen...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.255
更新日期:2009-03-01 00:00:00
abstract::In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA--U3, U14 and snR30--whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the pre-ribosome association to all 75 yeast snoRNAs in strains de...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.184
更新日期:2008-12-01 00:00:00
abstract::The ubiquitin-like protein Urm1 can be covalently conjugated to other proteins, such as the yeast thioredoxin peroxidase protein Ahp1p, through a mechanism involving the ubiquitin E1-like enzyme Uba4. Recent findings have revealed a second function of Urm1 as a sulphur carrier in the thiolation of eukaryotic cytoplasm...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2008.209
更新日期:2008-12-01 00:00:00
abstract::Processive motor proteins are stochastic steppers that perform actual mechanical steps for only a minor fraction of the time they are bound to the filament track. Motors usually work in teams and therefore the question arises whether the stochasticity of stepping can cause mutual interference when motors are mechanica...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.169
更新日期:2008-11-01 00:00:00
abstract::In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 antibody or expression of dominant-negative Rac1N17 led to an inversion ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.135
更新日期:2008-09-01 00:00:00
abstract::The intracellular modification of proteins by the addition of a single O-linked N-acetylglucosamine (O-GlcNAc) molecule is a ubiquitous post-translational modification in eukaryotic cells. It is catalysed by O-linked N-acetylglucosaminyltransferase, which attaches O-GlcNAc to serine/threonine residues, and it is count...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/embor.2008.129
更新日期:2008-08-01 00:00:00
abstract::The biosynthesis of RNA includes its post-transcriptional modifications, and the crucial functions of these modifications have supported their conservation within all three kingdoms. For example, the modifications located within or adjacent to the anticodon of the transfer RNA (tRNA) enhance the accuracy of codon bind...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.104
更新日期:2008-07-01 00:00:00
abstract::The Vav family of proteins are guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases, which regulate various cellular functions, including T-cell activation. They contain a catalytic Dbl homology (DH) domain that is invariably followed by a pleckstrin homology (PH) domain, which is often required fo...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.80
更新日期:2008-07-01 00:00:00
abstract::The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the ce...
journal_title:EMBO reports
pub_type: 杂志文章,收录出版
doi:10.1038/embor.2008.55
更新日期:2008-06-01 00:00:00
abstract::The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redundantly in the gut, as only simultaneous loss of both receptors r...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/embor.2008.7
更新日期:2008-04-01 00:00:00
abstract::The angiotensin II type 1 (AT(1)) receptor is a G protein-coupled receptor that has a crucial role in the development of load-induced cardiac hypertrophy. Here, we show that cell stretch leads to activation of the AT(1) receptor, which undergoes an anticlockwise rotation and a shift of transmembrane (TM) 7 into the li...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7401157
更新日期:2008-02-01 00:00:00
abstract::Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol 3,5-bisphosphate. ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7401155
更新日期:2008-02-01 00:00:00
abstract::The ubiquitous inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel is engaged by thousands of plasma membrane receptors to generate Ca(2+) signals in all cells. Understanding how complex Ca(2+) signals are generated has been hindered by a lack of information on the kinetic responses o...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7401087
更新日期:2007-11-01 00:00:00
abstract::The tubby loci provide a unique opportunity to study adult-onset obesity. Mutation in either mammalian tubby or its homologue in Caenorhabditis elegans, tub-1, results in increased fat storage. Previously, we have shown that TUB-1 interacts with a new Rab GTPase-activating protein, RBG-3, for the regulation of fat sto...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7401055
更新日期:2007-10-01 00:00:00
abstract::Histone deacetylases (HDACs)-an enzyme family that deacetylates histones and non-histone proteins-are implicated in human diseases such as cancer, and the first-generation of HDAC inhibitors are now in clinical trials. Here, we report the 2.0 A resolution crystal structure of a catalytically inactive HDAC8 active-site...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7401047
更新日期:2007-09-01 00:00:00
abstract::The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400958
更新日期:2007-06-01 00:00:00
abstract::In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulati...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400920
更新日期:2007-04-01 00:00:00
abstract::The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) eta is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol eta UBZ domain and its interaction with ubiquitin. We show that th...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400901
更新日期:2007-03-01 00:00:00
abstract::X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females. This dosage-compensati...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/sj.embor.7400871
更新日期:2007-01-01 00:00:00
abstract::The eukaryotic GINS complex has an essential role in the initiation and elongation phases of genome duplication. It is composed of four paralogous subunits--Sld5, Psf1, Psf2 and Psf3--which are ubiquitous and evolutionarily conserved in eukaryotic organisms. Here, we report the biochemical characterization of the huma...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400870
更新日期:2007-01-01 00:00:00
abstract::Retinoic acid (RA) signalling ensures that vertebrate mesoderm segmentation is bilaterally synchronized, and corrects transient interferences from asymmetric left-right (L-R) signals involved in organ lateralization. Snail genes participate in both these processes and, although they are expressed symmetrically in the ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400867
更新日期:2007-01-01 00:00:00
abstract::The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism a...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400849
更新日期:2007-01-01 00:00:00
abstract::Defects in protein folding and the proteasomal pathway have been linked with many neurodegenerative diseases. PLIC-1 (protein linking IAP to the cytoskeleton) is a ubiquitin-like protein that binds to the ubiquitin-interacting motif (UIM) of the proteasomal subunit S5a. Here, we show that PLIC-1 also binds to the UIM ...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400823
更新日期:2006-12-01 00:00:00
abstract::Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400817
更新日期:2006-11-01 00:00:00
abstract::Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosph...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400813
更新日期:2006-11-01 00:00:00
abstract::Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We previously described that lymphocyte-specific protein tyrosine kinase (LCK) and FYN oncogene related to SRC, FGR, YES (FYN) mediate GC-induced inhibition of T-cell-receptor (TCR) signalling. Her...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400775
更新日期:2006-10-01 00:00:00
abstract::Subcellular organization is yielding to large-scale analysis. Researchers are now applying robust mass-spectrometry-based proteomics methods to obtain an inventory of biochemically isolated organelles that contain hundreds of proteins. High-resolution methods allow accurate protein identification, and novel algorithms...
journal_title:EMBO reports
pub_type: 杂志文章,评审
doi:10.1038/sj.embor.7400780
更新日期:2006-09-01 00:00:00
abstract::The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400773
更新日期:2006-09-01 00:00:00
abstract::Post-translational protein arginylation is essential for cardiovascular development and angiogenesis in mice and is mediated by arginyl-transfer RNA-protein transferases Ate1-a functionally conserved but poorly understood class of enzymes. Here, we used sequence analysis to detect the evolutionary relationship between...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400747
更新日期:2006-08-01 00:00:00
abstract::The mechanism by which YopP simultaneously inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB pathways has been elusive. Ectopic expression of YopP inhibits the activity and ubiquitination of a complex consisting of overexpressed TGF-beta-activated kinase 1 (TAK1) and its subunit TAK1-binding p...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400754
更新日期:2006-08-01 00:00:00
abstract::Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP activity, inducing grow...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400737
更新日期:2006-07-01 00:00:00
abstract::gamma-Secretase-dependent regulated intramembrane proteolysis of amyloid precursor protein (APP) releases the APP intracellular domain (AICD). The question of whether this domain, like the Notch intracellular domain, is involved in nuclear signalling is highly controversial. Although some reports suggest that AICD reg...
journal_title:EMBO reports
pub_type: 杂志文章
doi:10.1038/sj.embor.7400704
更新日期:2006-07-01 00:00:00